Biocompatible rapid-gelating hydrogel and associated preparation method of spray

A preparation method for biocompatible rapid-gelating hydrogel, wherein it comprises the following steps:

• (1) Component A and component B mix to form reactive mixture with specific crosslinking conditions;
• component A is a solution containing biocompatible thiolated macromolecule derivatives, and component B is a biocompatible thiol-reactive crosslinking agent which can be a solid or a solution. Wherein, biocompatible thiolated macromolecule derivatives are prepared through thiolation for biocompatible macromolecules, the concentration of component A is less than 8% w/v, the pH value of component A is less than 8.5. The thiol in component A reacts with the thiol-reactive functional groups in component B for chemical crosslinking reaction, the sum of the concentration of biocompatible thiolated macromolecule derivative and the concentration of biocompatible thiol-reactive crosslinking agent in said reactive mixture is less than 6% w/v, and mentioned specific crosslinking conditions mean that the pH value of reactive mixture solution is >7.0 or ≦7.0;
• when the pH value of reactive mixture solution is higher than 7.0, the pH value of component B is higher than that of component A.
• (2) The reactive mixture forms hydrogel.