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US 2010/0144884 A1Published application
Novel 3-phenyl acrylic acid compound activators of type ppar receptors and pharmaceutical/cosmetic compositions comprised thereof
AssigneeGalderma Research & Development
InventorsJean-Guy BOITEAU, Laurence CLARY, Jean-Claude PASCAL, Sandrine CHAMBON
Life of this patent
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Abstract
Novel 3-phenyl acrylic acid compounds have the following general formula (I): and are formulated into pharmaceutical compositions for administration in human or veterinary medicine (in dermatology, as well as in the field of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or into cosmetic compositions.
Claims22
A 3-phenyl acrylic acid compound having the following general formula (I):
- in which:
- R1 is a hydroxyl radical or an alkoxy radical;
- R2 is an alkyl radical, an alkoxy radical, or an aralkoxy radical;
- R3 is a hydrogen atom, an alkyl radical, an optionally substituted aralkyl radical or a polyether radical;
- R4 is a hydrogen, a halogen, an alkyl radical or an alkoxy radical;
- R5 is an alkyl radical, an optionally substituted aryl radical or an optionally substituted aralkyl radical;
- X is an oxygen atom or a CH2 radical;
- Y is an oxygen atom, an NR6 radical, a radical OSO2, OCO, NR6CO or NR6SO2,
- R6 is a hydrogen atom or an alkyl radical;
- and also the salts thereof with a pharmaceutically acceptable acid or base,
- and the pharmaceutically acceptable solvates and hydrates thereof.
8 more elements
Dependencies are inferred from the claim text.