Compositions and Methods for Preserving Brain Function
OwnerBrian T. Larson, Samuel T. Henderson +1inventors
InventorsBrian T. Larson, Samuel T. Henderson, Matthew A. Roberts
Life of this patent
Estimating the term…
Abstract
Compositions and methods for preventing, reducing, or delaying decline in one or more of cognitive function, motor function, cerebrovascular function, or behavior in animals, particularly geriatric animals, are disclosed. The compositions and methods utilize medium chain triglycerides.
Claims71
A composition comprising medium chain triglycerides (MCTs), in an amount effective for preventing, reducing, or delaying decline in one or more of cognitive function, motor performance, cerebrovascular function, or behavior in an aging mammal, wherein said composition increases a circulating concentration of at least one ketone body in the mammal;
- and wherein the MCTs are of the formula:
- wherein the R1, R2, and R3 esterified to the glycerol backbone are each independently fatty acids having 5-12 carbons;
- wherein the aging mammal has reached at least about 50% of its life expectancy.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
A method for preventing, reducing, or delaying decline in at least one of cognitive function, motor function, cerebrovascular function, or behavior in an aging mammal comprising the steps of:
- identifying an aging mammal having, or at risk of, decline in at least one of cognitive function, motor function, cerebrovascular function, or behavior;
- and
- administering to the mammal on an extended regular basis a composition comprising medium chain triglycerides (MCTs) in an amount effective to prevent, reduce, or delay decline in at least one of cognitive function, motor function, cerebrovascular function, or behavior in the mammal wherein said composition increases the circulating concentration of at least one ketone body in the mammal;
- and wherein the MCTs are of the formula:
- wherein the R1, R2, and R3 esterified to the glycerol backbone are each independently fatty acids having 5-12 carbons.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
A method for preventing, reducing, or delaying decline in at least one of cognitive function, motor function, cerebrovascular function, or behavior in an aging mammal comprising the steps of:
- (a) identifying an aging mammal not having an age-related cognitive impairment disease;
- and
- (b) administering to the mammal, on an extended regular basis, a composition comprising medium chain triglycerides (MCTs) in an amount effective to prevent, reduce, or delay decline in at least one of cognitive function, motor function, cerebrovascular function, or behavior in the mammal;
- wherein said composition increases the circulating concentration of at least one ketone body in the mammal;
- and wherein the MCTs are of the formula:
- wherein the R1, R2, and R3 esterified to the glycerol backbone are each independently fatty acids having 5-12 carbons;
- (c) measuring the concentration of at least one ketone body, and at least one of cognitive function, motor function, cerebrovascular function, or behavior in the mammal at least periodically for the duration of the administering step;
- (d) comparing the at least one ketone body concentration and the measure of cognitive function, motor function, cerebrovascular function, or behavior to that of a control animal not receiving the administered composition;
- and
- (e) correlating the ketone body concentration with the measure of cognitive function, motor function, cerebrovascular function, or behavior thereby establishing the prevention, reduction, or delay of the decline of at least one of cognitive function, motor function, cerebrovascular function, or behavior as a result of the administration of the composition.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.