Treatment of myocarditis using fts
AssigneeRamot at Tel-Aviv University Ltd.
InventorsYoel Kloog, Jakob George, Gad Keren, Rakefet Pando
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Abstract
Disclosed are methods of treating myocarditis by—administering to a human in need thereof effective amounts of FTS, or various analogs thereof, or a pharmaceutically acceptable salt thereof.
Claims20
A method of treating a human afflicted with myocarditis comprising administering to the human an effective amount of farnesylthiosalicylic acid (FTS) or an analog thereof as represented by the formula:
- wherein
- R1 represents farnesyl or geranyl-geranyl;
- R2 is COOR7, or CONR7R8, wherein R7 and R8 are each independently hydrogen, alkyl or alkenyl;
- R3, R4, R5 and R6 are each independently hydrogen, alkyl, alkenyl, alkoxy, halo, trifluoromethyl, trifluoromethoxy, or alkylmercapto;
- and
- X represents S;
- or a pharmaceutically acceptable salt thereof.
A method for reducing the proliferative ability of lymphocytes comprising administering to the human an effective amount of farnesylthiosalicylic acid (FTS) or an analog thereof as represented by the formula:
- wherein
- R1 represents farnesyl or geranyl-geranyl;
- R2 is COOR7, or CONR7R8, wherein R7 and R8 are each independently hydrogen, alkyl or alkenyl;
- R3, R4, R5 and R6 are each independently hydrogen, alkyl, alkenyl, alkoxy, halo, trifluoromethyl, trifluoromethoxy, or alkylmercapto;
- and
- X represents S;
- or a pharmaceutically acceptable salt thereof.
A method of treating a human afflicted with myocarditis comprising orally administering to the human an effective amount of S-farnesylthiosalicylic acid.
Dependencies are inferred from the claim text.