Dna controlled assembly of lipid membranes
AssigneeSyddansk Universitet
InventorsStefan Vogel, Adam Cohen Simonsen
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Abstract
The present invention relates to detection of target nucleic acids by target nucleic acid induced liposome assembly. The invention provides oligonucleotides for use in detection and a method of detecting target nucleic acids. Other aspects of the invention are use of the oligonucleotide of the invention for detection, a kit for detection, a method of treatment comprising administrating the oligonucleotide of the invention and a pharmaceutical composition comprising the oligonucleotide of the invention.
Claims65
A method for constructing oligonucleotide-lipid architectures comprising:
- a. Providing one or more amphiphilic oligonucleotides, which alone or together comprise at least two membrane anchors;
- b. Providing a lipid membrane;
- and
- c. Incubating the one or more amphiphilic oligonucleotides with the lipid membrane, under conditions allowing insertion of the membrane anchors into the lipid membrane.
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An amphiphilic oligonucleotide comprising at least two membrane anchors, wherein said oligonucleotide is configured to allow insertion of the membrane anchors into a lipid membrane.
An oligonucleotide-lipid architecture comprising an oligonucleotide that comprises at least two membrane anchors joined to a lipid membrane.
Dependencies are inferred from the claim text.