Rnai therapeutic for respiratory virus infection
AssigneeMdrna, Inc.
InventorsJames Anthony McSwiggen, Qing Ge
Life of this patent
Estimating the term…
Abstract
Double stranded siRNA molecules for combatting a respiratory virus, wherein the strands of an siRNA molecule may be from about 15 to about 60 nucleotides, and uses thereof. One strand of an siRNA molecule can be a nucleic acid sequence identical to a conserved site, or a variant thereof, within the nucleic acid sequence of the respiratory virus.
Claims25
A double-stranded ribonucleic acid (dsRNA) molecule that decreases expression of a respiratory virus gene by RNA interference, wherein the dsRNA molecule has a double-stranded region of from about 15 to about 60 base pairs, the dsRNA molecule comprising:
- a. a first strand comprising from about 15 to about 60 nucleotides having a region of at least 15 contiguous nucleotides that are 100% complementary to a nucleic acid sequence of the respiratory virus gene, wherein the region of at least 15 contiguous nucleotides is present in a homologous gene of the virus in at least about 70% of the respiratory virus variants (strains) containing the homologous gene, except for no more than three (3) nucleotide mismatches among the region of at least 15 contiguous nucleotides;
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- b. a second strand comprising from about 15 to about 60 nucleotides that is at least 70% complementary to the first strand.
A double-stranded ribonucleic acid (dsRNA) molecule that decreases expression of a respiratory virus gene by RNA interference, wherein the dsRNA molecule has a double-stranded region of from about 15 to about 60 base pairs, the dsRNA molecule comprising:
- a. a first strand comprising from about 15 to about 60 nucleotides having a region of at least 15 contiguous nucleotides that are 100% complementary to a nucleic acid sequence of the respiratory virus gene selected from the group consisting of SEQ ID NOS. 1-16949, wherein the region of at least 15 contiguous nucleotides is present in a homologous gene of the virus in at least about 70% of the respiratory virus variants (strains) containing the homologous gene, except for no more than three (3) nucleotide mismatches among the region of at least 15 contiguous nucleotides;
- and
- b. a second strand comprising from about 15 to about 60 nucleotides that is at least 70% complementary to the first strand.
Dependencies are inferred from the claim text.