Novel indole derivatives as selective androgen receptor modulators (sarms)
AssigneeJanssen Pharmaceutica NV
InventorsJames C. Lantar, Zhihua Sui, James J. Fiordeliso, Weiqin Jiang, Xuqing Zhang
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Abstract
The present invention is directed to novel indole derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by the androgen receptor.
Claims7
-10. (canceled)
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of claim 1.
A pharmaceutical composition made by mixing a compound of claim 1 and a pharmaceutically acceptable carrier.
A process for making a pharmaceutical composition comprising mixing a compound of claim 1 and a pharmaceutically acceptable carrier.
A method of treating a disorder mediated by an androgen receptor, in a subject in need thereof comprising administering to the subject a therapeutically effective amount of the compound of claim 1.
A method of treating a condition selected from the group consisting of prostate carcinoma, benign prostatic hyperplasia (BPH), hirsitutism, alopecia, anorexia nervosa, breast cancer, acne, AIDS, cachexia, male contraception, and male performance, in a subject in need thereof comprising administering to the subject a therapeutically effective amount of the compound of claim 1.
The use of a compound as in claim 1 for the preparation of a medicament for treating:
- (a) prostate carcinoma, (b) benign prostatic hyperplasia, (c) hirsutism, (d) alopecia, (e) anorexia nervosa, (f) breast cancer, (g) acne, (h) AIDS, (i) cachexia, for (j) male contraception, or for (k) male performance enhancement, in a subject in need thereof.
Dependencies are inferred from the claim text.