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US 2010/0144810 A1Published application
Angiotensin ii receptor antagonists
AssigneeMerck Sharp & Dohme Corp.
InventorsMichael Man-Chu Lo, Amjad Ali, Ravi P. Nargund
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Abstract
A compound having the structure wherein R is an angiotensin receptor antagonist active group, and Y is Y is selected from the group consisting of R1 is selected from the group consisting of —O—C1-6 alkyl, —O-aryl, —O-heteroaryl, —O—C3-8 cycloalkyl, —C1-6 alkyl, -aryl, -heteroaryl, and —C3-8 cycloalkyl; R2 and R3 are independently selected from the group consisting of hydrogen and C1-4 alkyl, or a pharmaceutically acceptable salt or hydrate thereof, which is useful for treating hypertension.
Claims20
A compound having the general formula:
- wherein R is selected from the group consisting of
- Y is selected from the group consisting of
- provided that when Y is
- then R is
- R1 is selected from the group consisting of
- —O—C1-6 alkyl,
- —O-aryl,
- —O-heteroaryl,
- —O—C3-8 cycloalkyl,
- —C1-6 alkyl,
- -aryl,
- -heteroaryl, and
- —C3-8 cycloalkyl;
- R2 and R3 are independently selected from the group consisting of hydrogen and C1-4 alkyl, or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of the stereoisomer thereof.
11 more elements
A compound which is
- or a pharmaceutically acceptable salt thereof
Dependencies are inferred from the claim text.