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US 2010/0144786 A1Published application
Quinoline derivatives as crth2 receptor ligands
OwnerMichael Colin Cramp, Rosa Arienzo +7inventors
InventorsMichael Colin Cramp, Rosa Arienzo, George Hynd, Peter Crackett, Yann Griffon, Trevor Keith Harrison, Nicholas Charles Ray, Harry Finch, John Gary Montana
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Abstract
Specific quinoline derivatives are CRTH2 antagonists, useful in the treatment of conditions having an inflammatory component.
Claims6
A compound selected from the group consisting of:
- [3-(4-cyanobenzyl)-4-difluoromethoxy-2-ethyl-8-fluoroquinolin-5-yloxy]acetic acid,
- [3-(4-bromobenzyl)-4-difluoromethoxy-2-ethyl-8-fluoroquinolin-5-yloxy]acetic acid,
- [4-ethyl-8-fluoro-3-(4-methanesulfonylbenzyl)-2-methylquinolin-5-yloxy]acetic acid,
- [2-ethyl-8-fluoro-3-(4-methanesulfonylbenzyl)-4-methylquinolin-5-yloxy]acetic acid,
- [4-difluoromethoxy-2-ethyl-8-fluoro-3-(4-methoxycarbonylaminobenzyl)quinolin-5-yloxy]acetic acid,
- [4-difluoromethoxy-2-ethyl-8-fluoro-3-(3-methanesulfonylbenzyl)quinolin-5-yloxy]acetic acid,
- (S)-2-[3-(4-chlorobenzyl)-4-difluoromethoxy-2-ethyl-8-fluoroquinolin-5-yloxy]propionic acid,
- {4-difluoromethoxy-2-ethyl-8-fluoro-3-[4-(1-hydroxy-1-methylethyl)benzyl]quinolin-5-yloxy}acetic acid,
- [8-chloro-3-(4-cyanobenzyl)-4-difluoromethoxy-2-ethylquinolin-5-yloxy]acetic acid,
- [8-chloro-3-(2-chloro-4-cyanobenzyl)-4-difluoromethoxy-2-ethylquinolin-5-yloxy]acetic acid,
- [8-chloro-3-(4-cyanobenzyl)-2-difluoromethoxy-4-methylquinolin-5-yloxy]acetic acid,
- [3-(4-cyanobenzyl)-2-difluoromethoxy-8-fluoro-4-methylquinolin-5-yloxy]acetic acid, and salts, N-oxides, hydrates and solvates thereof.
9 more elements
(canceled)
4-5. (canceled)
Dependencies are inferred from the claim text.