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US 2010/0144783 A1Published application
Kinase inhibitors with improved cyp safety profile
AssigneeAbbott Laboratories
InventorMichael R. Michaelides
Life of this patent
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Abstract
Compounds that inhibit protein kinases such as Aurora-kinases and the VEGFR and PDGFR families of kinases, with an improved safety profile due to low CYP3A4 inhibition, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.
Claims5
A compound having Formula I
- or a therapeutically acceptable salt thereof,
- wherein
- R1 is hydroxyalkyl;
- R2 is selected from the group consisting of alkoxy, alkyl, halo, and haloalkoxy;
- and
- R3 is hydrogen or alkyl.
3 more elements
Dependencies are inferred from the claim text.