Method of Network-Based Identification of Multicomponent Synergy and Compositions for Use as Effective Component of Anti-Angiogenesis Medicines

Abstract

A method was provided for determining synergistic effect of a medicine combination including two medicines relating to a disease on the basis of a gene network and medicine-effective genes of each and/or any of said two medicines, comprising: determining a synergy factor (ST1,2) of said two medicines on the basis of distribution of medicine-effective genes of said two medicines; determining a medicine similarity factor (AS1,2) of said two medicines on the basis of similarity between set of symptoms which said two medicines relates to; and, determining extent of synergistic effect of said two medicines according to a product of said synergy factor and said similarity factor. Proposed were constructing a disease-related gene network, mapping medicine-effective genes onto the network, and determining extent of synergistic effect of medicines on the basis of the genes the present invention also relates to medicine composition of sinomenine and honokiol and medicine composition of sinomenine and luteolin, each with anti-angiogenesis effect having good synergistic effect. Effectiveness of the method of the invention had been verified by cell proliferation verification experiments.

Dependencies are inferred from the claim text.