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US 2010/0144768 A1Published application
Kinase inhibitor compounds
AssigneeXcovery Holding Company, LLC
InventorCongxin Liang
Life of this patent
Estimating the term…
Abstract
Pyrimidinone derivatives have enhanced and unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as inflammatory diseases and certain types of cancer.
Claims14
A compound of formula I:
- or a salt thereof;
- or a prodrug, or a salt of a prodrug thereof;
- or a hydrate, solvate, or polymorph thereof;
- wherein:
- R1, R2, R3, R4, R5, R6 are each independently hydrogen, halo, (C1-C3) alkyl, (C1-C3) alkoxy, and (C1-C3) alkylamino;
- R7 is hydrogen, halo, (C1-C6) alkyl, (C1-C6) alkoxy, and (C1-C6) alkylamino wherein the alkyl is optionally substituted by one or two groups that are independently hydroxyl, (C1-C3) alkoxy, and (C1-C3) alkylamino;
- R8 is C(O)NR9R10 or NHR11;
- R9 and R10 are each independently hydrogen, (C1-C6) alkyl, (C3-C8) cycloalkyl, (C3-C8) heterocyclyl, or R9 and R10 together with the nitrogen they are attached to form a (C3-C8) heterocycle;
- R11 is a (C3-C8) cycloalkyl or (C3-C8) heterocycle provided that the cycloalkyl or heterocycle is substituted by 1, 2, 3, or 4 groups that are independently oxo, hydroxyl, (C1-C6)alkyl, (C1-C3) alkoxy, (C1-C3) alkylamino, heterocycle, amide, hydroxyl(C1-C6)allyl, or (C1-C3)alkoxy(C1-C3)alkyl;
- X1, X2 are each independently N or CR4.
7 more elements
The composition and synthesis of the amines, (S)-3-Amino-1-(2-hydroxy-ethyl)-pyrrolidine-2,5-dione, (S)-3-Amino-1-(2-methoxy-ethyl)-pyrrolidine-2,5-dione.
Dependencies are inferred from the claim text.