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US 2010/0144767 A1Published application
Use of sodium channel blockers for the treatment of visceral pain or pain caused by cancer treatment
AssigneeWex Pharmaceuticals Inc.
InventorsKim Noel Fisher, Anh Ho Ngoc, Edge Renfeng Wang
Life of this patent
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Abstract
The invention provides methods for treating visceral pain and pain associated with therapy. The compounds useful in the methods of the invention are blockers of sodium ion channels, and in particular compounds that bind to the SS1 or SS2 extracellular mouth of the α-subunit thereof. Particularly useful compounds are saxitoxin and its derivatives and analogues and tetrodotoxin and its derivatives and analogues.
Claims40
A method for the treatment of visceral pain in a mammal, the method comprising administering to a mammal in need thereof an effective amount of a sodium channel blocker
- 5 that binds to the SS 1 or SS2 site of the extracellular region of an alpha subunit of a sodium channel.
Dependencies are inferred from the claim text.