Methods and Compositions for Treating or Preventing Narcotic Withdrawal Symptoms
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsGary PELTZ, David CLARK, Lawrence CHU
Life of this patent
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Abstract
This invention provides methods and pharmaceutical compositions for preventing or treating physical dependence and/or withdrawal associated with narcotic use, in particular by modulating a 5-HT3 receptor. Using a computational genetic approach in mice, a gene conserved between mice and humans was identified as candidate as a modulator of physical dependence to morphine. Administration of compounds that modulate 5-HT3 receptors was found to control withdrawal from morphine in mice and humans.
Claims66
A method for preventing or treating physical dependence and/or withdrawal symptoms associated with narcotic use in a subject, comprising administering to said subject an agent that modulates a 5-HT3 receptor.
A method for preventing or treating physical dependence and/or withdrawal symptoms associated with narcotic use in a subject, consisting of administering to said subject an agent that modulates a 5-HT3 receptor.
A method for preventing or treating physical dependence and/or withdrawal symptoms associated with narcotic use in a subject, consisting essentially of administering to said subject an agent that modulates a 5-HT3 receptor.
A method for preventing or treating physical dependence and/or withdrawal symptoms associated with narcotic use in a subject comprising administering to the subject a pharmaceutical composition comprising a narcotic and an agent that reduces physical dependence and/or withdrawal symptoms associated with use of said narcotic.
A method for preventing or treating physical dependence and/or withdrawal symptoms associated with narcotic use in a subject comprising administering to the subject a pharmaceutical composition consisting of a narcotic and an agent that reduces physical dependence and/or withdrawal symptoms associated with use of said narcotic.
A method for preventing or treating physical dependence and/or withdrawal symptoms associated with narcotic use in a subject comprising administering to the subject a pharmaceutical composition consisting essentially of a narcotic and an agent that reduces physical dependence and/or withdrawal symptoms associated with use of said narcotic.
A method for treating addiction to a narcotic in a subject comprising administering to said subject an agent that modulates a 5-HT3 receptor.
A pharmaceutical composition comprising a narcotic and an agent that reduces physical dependence and/or withdrawal symptoms associated with use of said narcotic.
A pharmaceutical composition consisting of a narcotic and an agent that reduces physical dependence and/or withdrawal symptoms associated with use of said narcotic.
A pharmaceutical composition consisting essentially of a narcotic and an agent that reduces physical dependence and/or withdrawal symptoms associated with use of said narcotic.
A method for treating or preventing physical dependence and/or withdrawal symptoms associated with narcotic use in a subject comprising administering to said subject an agent that modulates a 5-HT3 receptor and a second agent.
A method for treating or preventing physical dependence and/or withdrawal symptoms associated with narcotic use in a subject consisting of administering to said subject an agent that modulates a 5-HT3 receptor and a second agent.
A method for treating or preventing physical dependence and/or withdrawal symptoms associated with narcotic use in a subject consisting essentially of administering to said subject an agent that modulates a 5-HT3 receptor and a second agent.
A pharmaceutical composition comprising a narcotic and at least two agents that reduce physical dependence and/or withdrawal symptoms associated with use of said narcotic.
A pharmaceutical composition consisting of a narcotic and two agents that reduce physical dependence and/or withdrawal symptoms associated with use of said narcotic.
A pharmaceutical composition consisting essentially of a narcotic and two agents that reduce physical dependence and/or withdrawal symptoms associated with use of said narcotic.
Dependencies are inferred from the claim text.