Compositions and methods for inhibition of tyrosine kinases
AssigneeBoard of Regents, The University of Texas System
InventorsWilliam Bornmann, David Maxwell, Zhenghong Peng, Liwei Guo
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Abstract
Compositions for inhibiting the catalytic activity of tyrosine kinases comprising compounds represented by Formulas (I), (II), and (III). Methods for treating proliferative diseases comprising administering a therapeutically effective amount of the above compositions.
Claims12
A composition for inhibiting catalytic activity of a tyrosine kinase comprising a compound represented by Formula (I) or an enantiomer, diastereomer, pharmaceutically acceptable salt, hydrate, prodrug, or solvate thereof
- wherein R1 is selected from the group consisting of the following structures:
A composition for inhibiting catalytic activity of a tyrosine kinase comprising a compound represented by Formula (II) or an enantiomer, diastereomer, pharmaceutically acceptable salt, hydrate, prodrug, or solvate thereof
- wherein R1 is selected from the group consisting of the following structures
A composition for inhibiting catalytic activity of a tyrosine kinase comprising a compound of Formula (III) or an enantiomer, diastereomer, pharmaceutically acceptable salt, hydrate, prodrug, or solvate thereof
- wherein R1 is selected from the group consisting of the following structures:
- and wherein R2 is selected from the group consisting of the following structures:
Dependencies are inferred from the claim text.