Ethanolamine derivatives useful as bace inhibitors

A compound of the formula

• in which
• R1 is hydrogen, (C1-8)alkyl, a (C3-8)cycloalkyl, aryl or heteroaryl group, which (C3-8)cycloalkyl, aryl or heteroaryl group is optionally substituted by 1 to 4 substituents, independently selected from the group consisting of halogen, (C1-8)alkyl, halogen-substituted (C1-8)alkyl, (C1-8)alkoxy, (C1-8)alkoxy(C1-8)alkyl, (C3-8)cycloalkyl and an aryl or heteroaryl group, which aryl or heteroaryl group is optionally substituted by 1 to 4 substituents, independently selected from the group consisting of halogen, (C1-8)alkyl, halogen-substituted (C1-8)alkyl, hydroxy, (C1-8)alkoxy, (C1-8)alkoxy(C1-8)alkyl and (C3-8)cycloalkyl, a group of the formula
• in which X is O or S, the group of the formula Ia being optionally substituted by 1 or 2 substituents, independently selected from the group consisting of halogen and (C1-8)-alkyl, or a group of the formula
• R2 is hydrogen, halogen, (C1-8)alkyl, (C1-8)alkoxy, (C1-8)alkoxy(C1-8)alkyl, (C1-8)alkylthio or a (C3-8)cycloalkyl, (C3-8)cycloalkyl(C1-8)alkyl or (C3-8)cycloalkyl(C1-8)alkoxy group, in which (C3-8)cycloalkyl, (C3-8)cycloalkyl(C1-8)alkyl or (C3-8)cycloalkyl(C1-8)alkoxy group the (C3-8)-cycloalkyl moiety is optionally substituted by 1 to 4 substituents, independently selected from the group consisting of halogen and (C1-8)alkyl;
• either
• R3 is hydrogen and
• R4 is hydrogen, (C1-8)alkyl, halogen-substituted (C1-8)alkyl, (C1-8)alkoxy(C1-8)alkyl, (C1-8)alkylthio(C1-8)alkyl, (C1-8)alkylamino(C1-8)alkyl, a (C3-8)cycloalkyl, aryl or heteroaryl group, which (C3-8)cycloalkyl, aryl or heteroaryl group is optionally substituted by 1 to 4 substituents, independently selected from the group consisting of halogen, (C1-8)alkyl, halogen-substituted (C1-8)alkyl, (C1-8)alkoxy, (C1-8)alkoxy(C1-8)alkyl, (C3-8)cycloalkyl and an aryl or heteroaryl group, which aryl or heteroaryl group is optionally substituted by 1 to 4 substituents, independently selected from the group consisting of halogen, (C1-8)-alkyl, halogen-substituted (C1-8)alkyl, hydroxy, (C1-8)alkoxy, (C1-8)alkoxy(C1-8)alkyl and (C3-8)cycloalkyl, or a (C3-8)cycloalkyl group, in which (C3-8)cycloalkyl group one —CH2-moiety is replaced by —O— and which (C3-8)cycloalkyl group is optionally substituted by 1 or 2 substituents, independently selected from the group consisting of halogen and (C1-8)alkyl,
• or
• the moiety —N(R3)—C(═O)—R4 is a group of the formula
• which is optionally substituted by 1 or 2 substituents, independently selected from the group consisting of halogen and (C1-8)alkyl, or a group of the formula
• which is optionally substituted by 1 or 2 substituents, independently selected from the group consisting of halogen and (C1-8)alkyl;
• either
• R5 is hydrogen, (C1-8)alkyl, (C1-8)alkoxy(C1-8)alkyl or halogen-substituted (C1-8)alkyl and
• R6 is hydrogen or (C1-8)alkyl
• or
• R5 and R6 together are, together with the carbon atom, to which they are attached, a (C3-8)-cycloalkyl group, which (C3-8)cycloalkyl group is unsubstituted or substituted by 1 to 4 substituents, independently selected from the group consisting of halogen and (C1-8)alkyl;
• R7 is (C1-8)alkyl, (C3-8)cycloalkyl(C1-8)alkyl or halogen-substituted (C1-8)alkyl;
• T1 is CR8, N, O, S or a bond;
• R8 is hydrogen, halogen, (C1-8)alkyl, (C1-8)alkoxy or halogen-substituted (C1-8)alkyl;
• T2 is CR9, N, O, S or a bond;
• R9 is hydrogen, halogen, (C1-8)alkyl, (C1-8)alkoxy or halogen-substituted (C1-8)alkyl;
• T3 is CR10, N, O, S or a bond;
• R10 is hydrogen, halogen, (C1-8)alkyl, (C1-8)alkoxy or halogen-substituted (C1-8)alkyl;
• T4 is CR11, N, O or S;
• R11 is hydrogen, halogen, (C1-8)alkyl, (C1-8)alkoxy or halogen-substituted (C1-8)alkyl;
• the number of ring atoms included in the ring comprising T1 being 5 or 6;
• the number of hetero ring atoms included in the ring comprising T1 being 0, 1, 2 or 3;
• the hetero ring atoms optionally included in the ring comprising T1 being selected, if the number of ring atoms included in the ring comprising T1 is 5, in such a way, that any ring oxygen atom, which is optionally present, is separated from any other ring oxygen atom, which is optionally present, by at least one ring atom different from a ring oxygen atom;
• and the hetero ring atoms optionally included in the ring comprising T1 being selected, if the number of ring atoms included in the ring comprising T1 is 6, in such a way, that any ring oxygen atom, which is optionally present, is separated from any other ring hetero atom, which is optionally present, by at least one ring carbon atom,
• in free base form or in acid addition salt form.