Inhibitors of c-met and uses thereof

A compound of the structural Formula I

• or a salt, ester or prodrug, thereof, wherein:
• R1 is aryl or heteroaryl, optionally substituted by 1-3 substituents independently selected from acyl, acyloxy, alkoxy, halo, haloalkyl, heteroaryl, hydroxy, or nitro, cycloalkyl;
• R2 is aryl, optionally substituted by an alkyl group;
• and
• R3 is H;
• provided that:
• when R2 is p-tolyl and R3 is H, R1 is not phenyl, 3,4-dimethoxyphenyl, 2-thienyl or cyclohexyl.

A compound of the structural Formula II

• or salt, ester or prodrug, thereof, wherein:
• R1 is independently aryl or heteroaryl, optionally substituted by 1-3 substituents independently selected from acyl, acylamino, acyloxy, alkenyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylaminocarbonyl, alkylcarbonylalkyl, alkylthio, alkylthioalkyl, alkylsulfinyl, alkylsulfinylalkyl, alkynyl, amino, aminocarbonyl, aminoalkyl, aminocarbonylalkyl, aryl, arylamino, arylsulfonyl, arylthio, aralkyl, carboxy, carboxyalkyl, cyano, cycloalkyl, halo, haloalkyl, heteroaryl, heteroaralkyl, heterocyclo, heterocyclocarbonyl, hydroxy, hydroxyalkyl, methylenedioxy, or nitro;
• R2 is independently aryl or heteroaryl, optionally substituted by 1-3 substituents independently selected from acyl, acylamino, acyloxy, alkenyl, alkoxy, alkoxyalkyl, alkoxycarbonyl, alkoxycarbonylalkyl, alkyl, alkylaminocarbonyl, alkylcarbonylalkyl, alkylthio, alkylthioalkyl, alkylsulfinyl, alkylsulfinylalkyl, alkynyl, amino, aminocarbonyl, aminoalkyl, aminocarbonylalkyl, aryl, arylamino, arylsulfonyl, arylthio, aralkyl, carboxy, carboxyalkyl, cyano, cycloalkyl, halo, haloalkyl, heteroaryl, heteroaralkyl, heterocyclo, heterocyclocarbonyl, hydroxy, hydroxyalkyl, or nitro;
• R3 is independently selected from the group H, alkenyl, alkoxyalkyl, alkyl, alkynyl, cycloalkyl, cycloalkylalkyl, or haloalkyl;
• and
• X is independently selected from the group CO, SO2, SCO, or OCO;
• provided that:
• when R1 is 5-(1,3-benzodioxole), 3,4,5-trimethoxyphenyl, 3-nitrophenyl or 3,4-dimethoxyphenyl and R3 is H, and X is CO then R2 is not H, 2-thienyl, 3-pyridyl, 4-pyridyl or methyl;
• further provided that:
• when R1 is 2,5-dimethoxyphenyl, R3 is H and X is SO2, R2 is not H or 2-thienyl.

A compound of the structural Formula II

• or salt, ester or prodrug, thereof, wherein:
• R1 is aryl, optionally substituted by 1-3 substituents independently selected from alkoxy, methylenedioxy, or nitro;
• R2 is independently aryl or heteroaryl;
• R3 is H;
• and
• X is independently selected from the group CO, SO2, SCO, or OCO;
• provided that:
• when R1 is 5-(1,3-benzodioxole), R3 is H and X is CO, R2 is not 2-thienyl;
• when R1 is 3,4,5-trimethoxyphenyl, R3 is H and X is CO, R2 is not H, 2-thienyl or 3-pyridyl;
• R1 is 3-nitrophenyl, R3 is H and X is CO, R2 is not H or 2-thienyl;
• R1 is 3,4-dimethoxyphenyl, R3 is H and X is CO, R2 is not 2-thienyl, 3-pyridyl, 4-pyridyl or methyl;
• R1 is 2,5-dimethoxyphenyl, R3 is H and X is SO2, R2 is not H or 2-thienyl.