Methods for inhibiting t helper cell differentiation
AssigneeFibroGen, Inc.
InventorsFelice Aisha Chow, Stephen J. Klaus, Ingrid Langsetmo Parobok
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Abstract
The present invention relates to methods and compounds useful for inhibiting T helper cell differentiation. Methods and compounds for decreasing IL-12 signaling in T helper cells are also provided.
Claims5
A method for inhibiting the differentiation of a T helper cell into a Th1 cell, the method comprising contacting the T helper cell with an effective amount of a compound that inhibits the activity of a HIF prolyl hydroxylase enzyme, thereby inhibiting the differentiation of the T helper cell into a Th1 cell.
A method for inhibiting the differentiation of a T helper cell into a Th1 cell in a subject, the method comprising administering to the subject an effective amount of a compound that inhibits the activity of a HIF prolyl hydroxylase enzyme, thereby inhibiting the differentiation of the T helper cell into a Th1 cell in the subject.
A method for inhibiting IL-12 signaling in a T helper cell, the method comprising contacting the T helper cell with an effective amount of a compound that inhibits the activity of a HIF prolyl hydroxylase enzyme, thereby inhibiting IL-12 signaling in the T helper cell.
A method for inhibiting IFN-γ secretion from a T helper cell, the method comprising contacting the T helper cell with an effective amount of a compound that inhibits the activity of a HIF prolyl hydroxylase enzyme, thereby inhibiting the IFN-γ secretion from the T helper cell.
A method for inhibiting TNF-α secretion from a T helper cell, the method comprising contacting the T helper cell with an effective amount of a compound that inhibits the activity of a HIF prolyl hydroxylase enzyme, thereby inhibiting the TNF-α secretion from the T helper cell.
Dependencies are inferred from the claim text.