Compounds, compositions and methods comprising heteroaromatic derivatives

A compound of formula I:

• wherein:
• A is heteroaryl or substituted heteroaryl;
• L is a bond or a linker of 1 to 6 linear or branched covalently linked atoms;
• R1 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, alkoxy, substituted alkoxy, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, cycloalkyloxy, substituted cycloalkyloxy, cycloalkenyl, substituted cycloalkenyl, cycloalkenyloxy, substituted cycloalkenyloxy, heterocyclic, substituted heterocyclic, heterocyclyloxy, substituted heterocyclyloxy, aryloxy and substituted aryloxy;
• or R1 and L are taken together with the atom to which they are bonded to form a heterocycle or substituted heterocycle;
• R2 and R4 are each independently halo, amino or substituted amino;
• R3 is selected from the group consisting of hydrogen, hydroxyl, alkoxy and substituted alkoxy;
• and
• R5 is selected from the group consisting of hydrogen, hydroxyl, alkoxy and substituted alkoxy;
• or a pharmaceutically acceptable salt, isomer, or tautomer thereof;
• wherein said compound exhibits at least one of the following:
• a) an IC50 of less than 30 μM in the T84 assay;
• b) a greater than 30% inhibition at 20 μM in the FRT assay;
• or
• c) a greater than 35% inhibition at 50 μM in a T84 assay, provided that the compound does not have an IC50 greater than 30 μM.