Pyrimidine kinase inhibitors

A compound of formula I:

• wherein
• Q is —NR4—, —NR4C(O)—, —C(O)NR4—, —NR4C(O)O—, —OC(O)NR4—, —S(O)2NR4— or —NR4—C(O)—NR4;
• X is H, hydroxyl, halo, amino, nitro, alkyl or haloalkyl;
• Y is O, S or NR4;
• Z is H, alkyl, a carbocycle or a heterocycle, wherein said alkyl, carbocycles and heterocycles are optionally substituted with halogen, hydroxyl, carboxyl, amino, alkyl, a carbocycle or a heterocycle and wherein one or more CH2 groups of an alkyl group is optionally replaced with —O—, —S—, —S(O)—, S(O)2, —NR4—, —C(O)—, —C(O)—NR4—, —NR4—C(O)—, —SO2—NR4—, —NR4—SO2—, —NR4—C(O)—NR4—, —C(O)—O— or —O—C(O)—;
• R1 is hydroxyl, halogen, amino, oxo, thione, alkyl, a carbocycle or a heterocycle wherein said alkyl, carbocycles and heterocycles are optionally substituted with halogen, hydroxyl, carboxyl, amino, alkyl, a carbocycle or a heterocycle and wherein one or more CH2 groups of an alkyl group is optionally replaced with —O—, —S—, —S(O)—, S(O)2, —N(R4)—, —C(O)—, —C(O)—NR4—, —NR4—C(O)—, —SO2—NR4—, —NR4—SO2—, —NR4—C(O)—NR4—, —C(O)—O— or —O—C(O)—;
• R2 is hydroxyl, halogen, amino, carboxyl or is alkyl, acyl, alkoxy or alkylthio optionally substituted with hydroxyl, halogen, oxo, thione, amino, carboxyl or alkoxy;
• R4 is independently H or alkyl;
• m is 0 to 4;
• and
• n is 0 to 3.