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US 2010/0144729 A1Published application
Coumarin derivatives
OwnerRolf Baenteli, Nigel Graham Cooke +2inventors
InventorsRolf Baenteli, Nigel Graham Cooke, Frederic Zecri, Alexander Baxter Smith
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Abstract
A compound of formula (I) wherein R1, R2, R3 and R4 are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.
Claims11
A compound of formula I
- wherein
- each of R1 and R2, independently, is selected from the group consisting of hydrogen;
- halogen;
- nitro;
- optionally substituted C1-8alkyl;
- optionally substituted haloC1-8alkyl;
- optionally substituted C1-8alkoxy;
- and optionally substituted haloC1-8alkoxy,
- R3 is a saturated heterocyclic ring comprising at least one ring N atom and which is attached to ring A through a ring C atom, this or any other ring C atom being optionally substituted;
- R3 is in position 3 or 4;
- R4 is hydrogen;
- hydroxyl;
- halogen;
- haloC1-8alkyl;
- optionally substituted C1-6alkyl;
- C1-6alkoxy;
- or haloC1-6alkoxy;
- R4 is in position 2 or 3;
- or a physiologically hydrolysable derivative thereof, a salt, hydrate and/or solvate thereof.
16 more elements
(canceled)
9-10. (canceled)
A method for treating disorders or diseases mediated by lymphocytes, in a subject in need of such treatment, which method comprises administering to said subject an effective amount of a compound of formula I or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.