US 2010/0144708 A1 · HETEROCYCLIC COMPOUNDS CONTAINING NITROGEN ATOMS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME FOR TREATMENT OF CANCER

Heterocyclic compounds containing nitrogen atoms or pharmaceutically acceptable salts thereof, process for the preparation thereof and pharmaceutical composition comprising the same for treatment of cancer

AssigneesKorea Research Instititute of Bioscience and Biotechnology, Seoul Pharma. Co., Ltd.

InventorsGyoon Hee Han, Eun Hyun Choi, Jee Sun Yang, Sung Hee Hong, Myung Sook Kim, Mi Sun Won, Kyung Sook Chung, Dong Myung Kim, Hyang Sook Yoo, Hwan Mook Kim, Song Kyu Park, Ki Ho Lee, Chang Woo Lee, Youn Woong Choi, Yong Mi Jeong, Byung Gu Min

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Abstract

The present invention relates to new heterocyclic compounds containing nitrogen atoms or pharmaceutically acceptable salts thereof, a process for the preparation thereof, and a pharmaceutical composition comprising the same for treatment of cancer. The compounds according to the present invention induce DNA damage due to reactive oxygen species to activate c-abl and p53, induce RhoB to generate apoptosis, and induce cell death by down-regulating Bcl2 involved in cell survival, which is generated by dysregulated signals via the mitochondria pathway, thereby inhibiting tumor cell growth and inducing apoptosis. Accordingly, the composition according to the present invention can be used to treat cancer.

Claims8

Dependent claims

Heterocyclic compounds containing nitrogen atoms represented by Formula 1 or pharmaceutically acceptable salts thereof.

For the Formula 1,
R1 is straight or branched chain C1˜C30 alkyl, or C2˜C30 alkenyl,
R2 is straight or branched chain C1˜C6 alkyl,
R3 is straight or branched chain C1˜C6 alkyl;
C1˜C6 alkenyl;
allyl;
or benzyl substituted or unsubstituted with one group selected from the group consisting of straight or branched chain C1˜C6 alkyl, C1˜C6 alkoxy, OCF3, nitro, and halogen atom,
A is C(═O) or S(═O)2,
X is a halogen atom, and
n is an integer of 2 and 3.

7 more elements

Dependencies are inferred from the claim text.