Combination Medicaments for Treating Bacterial Infections

The method of claim 33, wherein the carbapenem antibiotic is a compound of formula (II)

• wherein
• R1 represents hydrogen or C1-C6alkyl;
• R2 represents hydrogen or C1-C6alkyl;
• R3 represents hydrogen, C1-C6alkyl, C1-C6alkoxy;
• —(C1nH2n)—R5 or —O—(C1nH2n)—R5;
• wherein
• R5 represents halogen, cyano, C1-C6alkoxy, amino;
• (C1-C6alkyl)amino, di(C1-C6alkyl)amino, or a group of formula CO—R6, —NH—CO—R6—CO—NH2, —NH—CO—NH2, —NH—SO2—NH2 or NH—(C═NH)—NH2, in which groups one or more of the hydrogen atoms may also be replaced with R6 or the —NH2 residue of the group can be replaced with a 5-6 membered heterocyclic ring bound to the group via a nitrogen atom present in the ring which heterocyclic ring may be unsubstituted or substituted with one or more of a substituent S2, wherein each S2 has independently of other substituents S2 one of the meanings defined below;
• and
• R6 represents C1-C6alkyl, phenyl or a 5-6 membered heterocyclic ring and may be unsubstituted or substituted with one or more of a substituent S1, wherein each S1 has independently of other substituents S1 one of the meanings defined below;
• and
• n is an integer from 1 to 6;
• R4 represents a group of formula —(S)m—R7, wherein
• m is 0 or 1 and
• R7 represents hydrogen;
• C1-C6alkyl, unsubstituted or substituted with one or more of a substituent S1;
• phenyl, unsubstituted or substituted with one or more of a substituent S1;
• or a 3-6 membered heterocyclyl group containing one or more than one heteroatom selected from nitrogen, sulfur and oxygen, which heterocyclyl group may furthermore optionally be fused to a phenyl ring or a 5-6 membered heterocyclic ring and which whole group is unsubstituted or substituted with one or more of a substituent S1;
• wherein each
• S1 is independently of other substituents S1 selected C1-C6alkyl, unsubstituted or substituted with one or more of a substituent S2;
• phenyl, unsubstituted or substituted with one or more of a substituent S2;
• or a 3-6 membered heterocyclyl group containing one or more than one heteroatom selected from nitrogen, sulfur and oxygen, which heterocyclyl group may furthermore optionally be fused to a phenyl ring or a 5-6 membered heterocyclic ring and which whole group is unsubstituted or substituted with one or more of a substituent S2;
• C1-C6alkoxy, hydroxyl, carboxy, amino, (C1-C6alkyl)amino, di(C1-C6)alkyl amino, cyano, halogen, or a group of formula —CO—R8, —NH—CO—NH2, —CO—NH2, —(C═NH)—C1-C6alkyl, —NH—CH═NH, —NH—CO—NH2, —NH—SO2—NH2 or NH—(C═NH)—NH2, in which groups one or more of the hydrogen atoms may also be replaced with R8 or the —NH2 residue of the group can be replaced with a 5-6 membered heterocyclic ring bound to the group via a nitrogen atom present in the ring which heterocyclic ring may be unsubstituted or substituted with one or more of a substituent S2, wherein each S2 has independently of other substituents S2 one of the meanings defined below;
• and
• R8 represents C1-C6alkyl, unsubstituted or substituted with one or more of a substituent S2;
• phenyl, unsubstituted or substituted with one or more of a substituent S2;
• or a 3-6 membered heterocyclyl group containing one or more than one heteroatom selected from nitrogen, sulfur and oxygen, which heterocyclyl group may furthermore optionally be fused to a phenyl ring or a 5-6 membered heterocyclic ring and which whole group is unsubstituted or substituted with one or more of a substituent S2, wherein each
• S2 is independently from other substituents S2 selected from C1-C6alkyl, unsubstituted or substituted with one or more of a substituent S3;
• phenyl, unsubstituted or substituted with one or more of a substituent S3;
• or a 3-6 membered heterocyclyl group containing one or more than one heteroatom selected from nitrogen, sulfur and oxygen, which heterocyclyl group may furthermore optionally be fused to a phenyl ring or a 5-6 membered heterocyclic ring and which whole group is unsubstituted or substituted with one or more of a substituent S3;
• C1-C6alkoxy, hydroxyl, carboxy, amino, (C1-C6)alkyl)amino, di(C1-C6)alkyl amino, cyano, halogen, or a group of formula —CO—R9, —NH—CO—R9;
• —CO—NH2, —NH—CH═NH, —NH—CO—NH2, —NH—SO2—NH2 or —NH—(C═NH)—NH2, in which groups one or more of the hydrogen atoms may also be replaced with R9 or the —NH2 residue of the group can be replaced with a 5-6 membered heterocyclic ring bound to the group via a nitrogen atom present in the ring which heterocyclic ring may be unsubstituted or substituted with one or more of a substituent S3, wherein each S3 has independently of other substituents S3 one of the meanings defined below;
• and
• R9 represents C1-C6alkyl, unsubstituted or substituted with one or more of a substituent S3;
• phenyl, unsubstituted or substituted with one or more of a substituent S3;
• or a 3-6 membered heterocyclyl group containing one or more than one heteroatom selected from nitrogen, sulfur and oxygen, which heterocyclyl group may furthermore optionally be fused to a phenyl ring or a 5-6 membered heterocyclic ring and which whole group is unsubstituted or substituted with one or more of a substituent S3, wherein each
• S3 independently of other substituents S3 represents unsubstituted C1-C6alkyl, unsubstituted phenyl or an unsubstituted 5-6 membered heterocyclic ring;
• C1-C6alkoxy, hydroxyl, carboxy, amino, (C1-C6alkyl)amino, di(C1-C6)alkyl amino, cyano, halogen, or a group of formula —NH—CO—NH2, —CO—NH2, —NH—CH═NH, —NH—CO—NH2, —NH—SO2—NH2 or —NH—(C═NH)—NH2;
• or R3 and R4 together form a C3-C7 polymethylene group, which is unsubstituted or substituted with one or more of a substituent S3, wherein each S3 has independently of other substituents S3 one of the meanings defined above,
• or a pharmaceutically acceptable salt thereof.