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AssigneeRenovo Limited
InventorsMark W. J. Ferguson, Nicholas Occleston, Sharon O'Kane, Nicholas Goldspink, Kerry Nield
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Provided are antagonists of FXR activity for use as medicament for the prevention, reduction or inhibition of scarring. This use may preferably be to prevent, reduce or inhibit scarring formed on healing of wounds. The invention also provides corresponding methods of treatment. Preferred antagonists of FXR activity include guggulsterone (Z); guggulsterone (E); a scalarane; 80-574; and a 5α-bile alcohol. In advantageous embodiments, up to 32 μM of the antagonist of FXR activity may be provided per linear cm of wound, or cm2 of a wound or fibrotic disorder, over a 24 hour period in order to inhibit scarring.
The use of an antagonist of FXR activity in the manufacture of a medicament for the prevention, reduction or inhibition of scarring.
The use of an antagonist of FXR activity in the manufacture of a medicament for the promotion of wound contraction.
The use according to any preceding claim, wherein the medicament is for use in the prevention, reduction or inhibition of scarring, and/or promotion of wound contraction, in the skin.
The use according to any preceding claim, wherein the medicament is a topical medicament.
The use according to any preceding claim, wherein the medicament is an injectable solution.
The use according to any preceding claim, wherein the medicament provides up to 32 μM of the antagonist of FXR activity per linear cm of wound, or cm2 of a wound or fibrotic disorder, over a 24 hour period.
A method of preventing, reducing or inhibiting scarring, the method comprising administering a therapeutically effective amount of an antagonist of FXR activity, to a patient in need of such prevention, reduction or inhibition.
A method of promoting wound contraction, the method comprising administering a therapeutically effective amount of an antagonist of FXR activity, to a patient in need of such promoted wound contraction.
Dependencies are inferred from the claim text.