Methods for generating mammalian models of atopic diseases, and screening for their treatment
AssigneeAssociation Pour La Recherche A L'igbmc (Ari)
InventorsPierre Chambon, Daniel Metzger, Mei Li
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Abstract
The present invention concerns a method for generating a human atopic disease-like phenotype, preferably an atopic dermatitis (AD)-like phenotype in a mammal comprising administering to said mammal at least one compound selected in the group comprising the physiologically active vitamin D3 (1α,25(OH)2D3) and agonistic analogs thereof. The present invention also concerns a method for treating and/or preventing an atopic disease in a patient in a patent comprising administrating to said patient an effective amount of at least one vitamin D3 antagonist.
Claims34
A method for generating a human atopic disease-like phenotype in a non human mammal, comprising the step (i) of administrating to said mammal at least one compound selected in the group comprising the physiologically active vitamin D3 (1α,25(OH)2D3) and agonistic analogs thereof.
Use of a composition comprising at least one vitamin D3 antagonist analog for the manufacture of a medicament for treating and/or preventing an atopic disease in a patent.
Dependencies are inferred from the claim text.