Pharmaceutical compositions useful for preventing and treating oncological diseases

Pharmaceutical composition for prevention and/or treatment of cancer diseases comprising therapeutically effective amount of a compound of formula (I)

• wherein A is effector moiety—antioxidant
• and/or reduced form thereof
• wherein m is an integer from 1 to 3;
• each Y is independently selected from the group consisting of:
• lower alkyl, lower alkoxy;
• or two adjacent Y groups, together with carbon atoms to which they are attached, form a following structure:
• and/or reduced form thereof
• wherein R1 and R2 may be the same or different and are each independently lower alkyl or lower alkoxy;
• L—linker group, comprising:
• a) straight or branched hydrocarbon chain which can be optionally substituted by one or more substituents and optionally contains one or more double or triple bonds;
• b) natural isoprene chain;
• n is integer from 1 to 20;
• B—targeting group, comprising
• a) Skulachev-ion Sk:
• Sk+Z−
• where Sk—lipophilic cation, Z—pharmacologically acceptable anion;
• b) charged hydrophobic peptide containing 1-20 amino acid residues;
• with proviso that in compound of structure (I) A is not ubiquinone (e.g. 2-methyl-4,5-dimethoxy-3,6-dioxo-1,4-cyclohexadienyl) or tocopherol or mimetic of superoxide dismutase or ebselen;
• while L—divalent decyl or divalent pentyl or divalent propyl radical;
• and while B is triphenylphosphonium cation;
• or solvates, isomers and prodrugs;
• and pharmaceutically acceptable carrier thereof.