Medication kits and formulations for preventing, treating or reducing secondary fractures after previous fracture
AssigneeDuke University
InventorKenneth W. Lyles
Life of this patent
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Abstract
The present invention provides a multi-component kit comprising a therapeutically effective amount of a bisphosphonate or analogue thereof in combination with an effective amount of Vitamin D, a metabolite thereof, a precursor thereof or an analogue thereof, wherein the kit provides instructions for daily dosing and correct chronological order of administration of components to provide a dosing regime for reducing secondary osteoporotic skeletal fractures in subjects at risk for vitamin D deficiency.
Claims15
A kit for reducing secondary osteoporotic skeletal fractures in subject at risk for vitamin D deficiency, the kit comprising a therapeutically effective amount of a bisphosphonate or analogue thereof in combination with an effective amount of Vitamin D, a metabolite thereof, a precursor thereof or an analogue thereof, wherein the Vitamin D is packaged in daily doses for administration before the bisphosphonate.
A multi-component kit for a patient at risk for secondary osteoporotic skeletal fractures and vitamin D deficiency, the kit comprising (a) Vitamin D or functional analogue thereof;
- (b) zoledronic acid or functional analogue thereof and optionally a calcium containing component.
A method for protecting a patient at risk for secondary osteoporotic skeletal fractures and vitamin D deficiency comprising the steps of:
- providing a container sized for inclusion of a sufficient amount of Vitamin D for a dosing regime comprising multiple dosages and a single dosage of a bisphosphonate;
- and
- providing instructions for the dosing regime.
A composition kit comprising at least two portions wherein multiple doses of Vitamin D or an analogue thereof are packaged in a first portion and at least one dose of zoledronic acid is packaged in a second portion
A kit comprising at least a first and a second product, wherein the second product is administered to a subject after sequentially administering the first product, and wherein the first product comprises a form of Vitamin D and the second product is zoledronic acid, a salt or hydrate thereof.
A method of treating bone disease and Vitamin D deficiency, comprising:
- a) opening a sealed disposable package, wherein the package comprises multiple single-unit doses of Vitamin D and optionally calcium;
- b) administering a single-unit dose, wherein steps a) to b) are repeated daily for a period of 10 to 31 days;
- and
- c) opening a vial contained within the sealed disposable package, wherein the vial comprises a single-unit dose of zoledronic acid or analogue thereof.
Dependencies are inferred from the claim text.