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US 2010/0144667 A1Published application
Methods for fucoidan purification from sea weed extracts
AssigneesBaxter International Inc., Baxter Healthcare S.A.
InventorsPatrick N. Shaklee, Jennifer Bahr-Davidson, Srinivasa Prasad, Kirk Johnson
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Abstract
Methods for purifying fucoidan in extracts from brown seaweed are disclosed. In particular, methods of purifying fucoidan in the extract to remove heavy metal ions, bacterial and endotoxin contaminants, and other impurities are disclosed. The methods include the use of a chelating agent, selective precipitation, and filtration.
Claims28
A method for purifying fucoidan from a heterogeneous mixture, the method comprising:
- (a) providing a source of fucoidan;
- (b) removing heavy metal ions from said source by treating with a chelating agent to produce a first fucoidan mixture;
- (c) selectively precipitating fucoidan present in said first fucoidan mixture to remove contaminants;
- (d) resuspending fucoidan-containing precipitate in aqueous solution to produce a second fucoidan mixture;
- (e) repeating steps (c) and (d) one or more times;
- and
- (f) filtering the aqueous solution comprising fucoidan to remove bacterial and endotoxin contaminants to yield purified fucoidan.
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Dependencies are inferred from the claim text.