Treatment of statin side effects

Use of uridine, one of its biological precursors or a salt, ester, tautomer or analogue thereof and at least one compound of Formula (I)

• wherein
• R1 is selected from H or C1-16 alkyl
• R2 and R3 are each independently selected from H, hydroxy, C1-16 alkyl, C1-6 alkoxy, C1-6 alkenyl, C1-6 alkenoxy, C1-6 alkynyl or C1-6 alkynoxy;
• and
• R4 is alkyl, alkenyl, alkoxy, alkenoxy, alkylol or alkenylol;
• in preparation of a medicament for treatment of one or more side effects of statin therapy.

A composition comprising uridine, one of its biological precursors or a salt, ester, tautomer or analogue thereof and at least one compound of Formula (I)

• wherein
• R1 is selected from H or C1-16 alkyl
• R2 and R3 are each independently selected from H, hydroxy, C1-16 alkyl, C1-6 alkoxy, C1-6 alkenyl, C1-6 alkenoxy, C1-6 alkynyl or C1-6 alkynoxy;
• and
• R4 is alkyl, alkenyl, alkoxy, alkenoxy, alkylol or alkenylol.

A combination pack or kit comprising uridine, one of its biological precursors or a salt, ester, tautomer or analogue thereof and at least one compound of Formula (I)

• wherein
• R1 is selected from H or C1-16 alkyl
• R2 and R3 are each independently selected from H, hydroxy, C1-16 alkyl, C1-6 alkoxy, C1-6 alkenyl, C1-6 alkenoxy, C1-6 alkynyl or C1-6 alkynoxy;
• and
• R4 is alkyl, alkenyl, alkoxy, alkenoxy, alkylol or alkenylol;
• wherein said pack or kit is adapted for the simultaneous, sequential or separate administration of the uridine, one of its biological precursors or a salt, ester, tautomer or analogue thereof and the compound of Formula (I).

A combination pack or kit comprising at least one statin, uridine, one of its biological precursors or a salt, ester, tautomer or analogue thereof and at least one compound of Formula (I)

• wherein
• R1 is selected from H or C1-16 alkyl
• R2 and R3 are each independently selected from H, hydroxy, C1-16 alkyl, C1-6 alkoxy, C1-6 alkenyl, C1-6 alkenoxy, C1-6 alkynyl or C1-6 alkynoxy;
• and
• R4 is alkyl, alkenyl, alkoxy, alkenoxy, alkylol or alkenylol;
• wherein said pack or kit is adapted for the simultaneous, sequential or separate administration of the statin, uridine, one of its biological precursors or a salt, ester, tautomer or analogue thereof and the compound of Formula (I).

A method of treatment of muscle pain and/or fatigue comprising administering to a subject in need of such treatment an effective amount of at least one compound of Formula (I)

• wherein
• R1 is selected from H or C1-16 alkyl
• R2 and R3 are each independently selected from H, hydroxy, C1-6 alkyl, C1-6 alkoxy, C1-6 alkenyl, C1-6 alkenyloxy, C1-6 alkynyl or C1-6 alkynyloxy;
• and
• R4 is alkyl, alkenyl, alkoxy, alkylol or alkenylol.

A method of treatment of a side effect of a drug therapy comprising administering to a subject in need of such treatment an effective amount of at least one compound of Formula (I)

• wherein
• R1 is selected from H or C1-16 alkyl
• R2 and R3 are each independently selected from H, hydroxy, C1-6 alkyl, C1-6 alkoxy, C1-6 alkenyl, C1-6 alkenyloxy, C1-6 alkynyl or C1-6 alkynyloxy;
• and
• R4 is alkyl, alkenyl, alkoxy, alkylol or alkenylol.