Carbocyclic compounds and methods for treating emerging disease, including influenza and venezuela equine encephalitis virus

A nucleoside compound according to the structure:

• Wherein R is H or F;
• R1 and R1a are each independently H, an acyl group, a C1-C20 alkyl or ether group, an amino acid residue, a phosphate, diphosphate, triphosphate or phosphodiester group or together R1 and R1a form a carbodiester or phosphodiester group with the oxygen atoms to which they are bonded;
• R2 is H, an acyl group, a C1-Cm alkyl or ether group or an amino acid residue;
• or a pharmaceutically acceptable salt, enantiomer, hydrate or solvate thererof.