Back to results
US 2010/0144662 A1Published application
Aminoglycoside antibiotics targeting bacterial 16s ribosomal rna
AssigneesEidgenoessische Technische Hochschule Zurich, Universitat Zurich Prorektorat Forschung
InventorsErik C. Boettger, Andrea Vasella, Déborah Perez Fernandez
Life of this patent
Estimating the term…
Abstract
The present invention relates to paromamine-based compounds according to formula I having selective antimicrobial activity directed at ribosomal 16S RNA. Furthermore, the invention is directed to the use of said compounds for preparing a medicament, pharmaceutical preparations and methods for preparing said compounds
Claims16
1-56. (canceled)
Compounds of formula (I):
- wherein:
- X, Y and Z denote in each case, independently of one another, —O—, —NH—, —S—, substituted or unsubstituted —CH2— or a direct bond to R1 and/or R2;
- R1 and R2 denote in each case, independently of one another, hydrogen, linear or branched, substituted or non-substituted alkyl, alkenyl, alkynyl, alkylidene, carbocycle or YR1 and ZR2 together form a substituted or non-substituted cycloalkyl or a corresponding heterocyclic ring, with the proviso that R1 and R2 are not both H,
- R3 and R4 denote in each case, independently of one another, hydrogen, amino or hydroxyl;
- R5 denotes glycosyl residues;
- and
- R6 denotes hydrogen
- and their diastereoisomers or enantiomers in the form of their bases or salts of physiologically compatible acids.
5 more elements
Dependencies are inferred from the claim text.