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US 2010/0144653 A1Published application
Fatty acid carbohydrate hybrid molecules as therapeutic agents and methods thereof
AssigneeThe Johns Hopkins University
InventorsKevin J. Yarema, Srinivasa-Gopalan Sampathkumar, Mark B. Jones, Christopher T. Campbell, Udayanath Aich
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Abstract
Described herein are fatty acid carbohydrate hybrid compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.
Claims28
A compound of formula (I), or pharmaceutically acceptable salt, solvate or hydrate thereof:
- wherein,
- each R′ is independently is H, —C(O)alkyl or —C(O)(CH2)nCH3;
- n is an integer 1-18;
- and
- each R is independently alkyl or alkenyl, each optionally substituted with 1-4 substituents selected from acyl, oxo, azido, aryl, halogen, —OC(O)alkyl, or —SC(O)alkyl.
2 more elements
(canceled)
15-23. (canceled)
25-31. (canceled)
(canceled)
41-43. (canceled)
A compound of formula (II), or pharmaceutically acceptable salt, solvate or hydrate thereof:
- wherein,
- each R′ is independently is H, —C(O)alkyl or —C(O)(CH2)nCH3;
- each R″ is independently is OH, OR′, or F;
- n is an integer 1-18;
- and
- each R is independently alkyl or alkenyl, each optionally substituted with 1-4 substituents selected from acyl, azido, aryl, halogen, —OC(O)alkyl, or —SC(O)alkyl.
3 more elements
Dependencies are inferred from the claim text.