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US 2010/0144651 A1Published application
Novel glucopyranose esters and glucofuranose esters of alkyl- fumarates and their pharmaceutical use
AssigneeAditech Pharma AB
InventorsHenrik Nilsson, Jens E.T. Andersen
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Abstract
The present invention relates to novel glucofuranose esters and glucopyranose esters of alkyl-fumarates. The esters are suitable for use as active substances in the treatment of e.g. psoriasis or other hyperproliferative, inflammatory or autoimmune disorders.
Claims28
A compound of the general formula (I) or (II)
- wherein R1, R2, R3, R4, R5, R6, R7, R8 and R9 are the same or different and each is selected from the group consisting of hydrogen, hydroxyl, methoxy, methoxymethoxy, benzyloxy, acetate, acetonide and X, and
- R10 is selected from the group consisting of hydrogen, hydroxyl, —CH2OH, —CH3, X and —CH2—X,
- wherein
- X is —OOC—CH═CH—COOR (trans) wherein R is C1-5alkyl;
- with the proviso that at least one of R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10 is X or R10 is —CH2X,
- and enantiomers, racemates, diastereomers, anomers or tautomeric forms or mixtures thereof.
3 more elements
21-28. (canceled)
35-38. (canceled)
Dependencies are inferred from the claim text.