Methods for modulating set and uses thereof
AssigneeCognosci, Inc.
InventorsMichael P. Vitek, Dale J. Christensen, Jessica Oddo
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Abstract
The present invention provides methods for modulating SET activity by contacting SET with a binding agent such as an ApoE peptide derivative. In one embodiment of the invention, a pharmaceutical composition capable of modulating SET activity is administered to a patient for the treatment of an inflammatory or neurological condition. In another embodiment of the invention, compounds efficacious for the treatment of inflammatory and neurological conditions are identified by screening for a binding agent capable of competing with or inhibiting the binding of an ApoE derivative to SET.
Claims58
A method of modulating an activity of SET comprising contacting SET with an exogenous agent capable of binding SET.
A method of identifying an agent that binds to SET and modulates SET activity, comprising
- contacting SET with at least one test agent to identify one or more agents that bind to SET, and
- screening said one or more agents for the ability to compete with or inhibit binding of a peptide containing SEQ ID NO:
- 1 to SET.
A method of increasing the pool of active PP2A in a cell comprising
- administering an agent to said cell wherein said agent binds to SET preventing SET from binding to PP2A.
Dependencies are inferred from the claim text.