Treatment of Multi-Drug Resistant Bacterial Infections
OwnerMalcolm Philip Young, Catherine Mary Thomas +2inventors
InventorsMalcolm Philip Young, Catherine Mary Thomas, Olusola Clement Idowu, Julie Anne Charlton
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Abstract
There is described an imidazole for the treatment of an infection caused or contributed to by microorganisms resistant to antibiotics. There is also described a method of treating a patient suffering from an infection caused or contributed to by microorganisms resistant to antibiotics, said method comprising the step of administering an effective amount of an imidazole.
Claims19
1-43. (canceled)
An imidazole selected from the group consisting of clotrimazole, 1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole (C22H17ClN2);
- econazole, 1-[2-[(4-cholorphenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole;
- miconazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole;
- butonazole, (±)-1-[4-(4-chlorophenyl)-2[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole;
- fenticonazole, 1-[2-(2,4-Dichlorophenyl)-2-[[4-phenylthio)phenyl]methoxy]ethyl-1H-imidazole;
- oxiconazole nitrate, (Z)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanone O-[2,4-dichlorophenyl)-methyl]oxime mononitrate;
- sertaconazole, 1-[2-[(7-chlorobenzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)-ethyl]imidazole;
- sulconazole, 1-[2-[[(4-chlorophenyl)methyl]-thio]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole;
- and tioconazole, 1-[2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichloro phenyl)ethyl-1H-imidazole;
- and derivatives thereof, for the treatment of an infection caused or contributed to by microorganisms resistant to antibiotics.
An imidazole selected from the group consisting of clotrimazole, 1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole (C22H17ClN2);
- econazole, 1-[2-[(4-cholorphenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole;
- miconazole, 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole;
- butonazole, (±)-1-[4-(4-chlorophenyl)-2[(2,6-dichlorophenyl)thio]butyl]-1H-imidazole;
- fenticonazole, 1-[2-(2,4-Dichlorophenyl)-2-[[4-phenylthio)phenyl]methoxy]ethyl]-1H-imidazole;
- oxiconazole nitrate, (Z)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanone O-[2,4-dichlorophenyl)-methyl]oxime mononitrate;
- sertaconazole, 1-[2-[(7-chlorobenzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)-ethyl]imidazole;
- sulconazole, 1-[2-[[(4-chlorophenyl)methyl]-thio]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole;
- and tioconazole, 1-[2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichloro phenyl)ethyl]-1H-imidazole;
- and derivatives thereof, for the prophylactic use against an infection caused or contributed to by microorganisms resistant to antibiotics.
A method of treating a patient suffering from an infection caused or contributed to by microorganisms resistant to antibiotics, said method comprising the step of administering a therapeutically effective amount of an imidazole selected from the group consisting of clotrimazole;
- econazole;
- miconazole;
- butonazole;
- fenticonazole;
- oxiconazole nitrate;
- sertaconazole;
- sulconazole;
- and tioconazole;
- and derivatives thereof.
The use of an imidazole selected from the group consisting of clotrimazole;
- econazole;
- miconazole;
- butonazole;
- fenticonazole;
- oxiconazole nitrate;
- sertaconazole;
- sulconazole;
- and tioconazole;
- and derivatives thereof in the manufacture of an antibacterial agent against microorganisms resistant to antibiotics wherein the antibacterial agent is at least one of a sterilising agent and a cleaning agent.
Dependencies are inferred from the claim text.