Nucleotide sequence encoding a modulator of nf-kb
AssigneeInstitut Pasteur
InventorsShoji Yamaoka, Gilles Courtois, Alain Israel, Robert Weil
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Abstract
The present invention relates to nucleotide sequences encoding a modulator of NF-κB, and to the polypeptides encoded by the nucleotide sequences. In particular, the invention relates to nucleotide sequences and the polypeptides encoded thereby, wherein the polypeptides are involved in the response to NF-κB-activating stimuli, including HTLV-1 Tax, LPS, PMA and IL-1. The invention also relates to antibodies to the modulator of NF-κB, methods of detecting modulator of NF-κB using the antibodies, methods of treatment associated with NF-κB activation and to methods of identifying compounds which modulate the activity of the modulator of NF-κB.
Claims17
1-50. (canceled)
A purified modulator of NF-κB comprising a polypeptide having an amino acid sequence that is at least 95% homologous to SEQ ID NO:
- 1, or an active fragment thereof, wherein the purified modulator of NF-κB possesses the following structural and functional characteristics:
- a) an apparent molecular weight of approximately 48 kD;
- b) a pI of approximately 5.66;
- c) containing a leucine zipper motif;
- and
- d) binding to a kinase involved in the activation of NF-κB.
A purified modulator of NF-κB comprising a polypeptide encoded by a polynucleotide sequence that is at least 95% homologous to SEQ ID NO:
- 2, or an active fragment thereof, wherein the purified modulator of NF-κB possesses the following structural and functional characteristics:
- a) an apparent molecular weight of approximately 48 kD;
- b) a pI of approximately 5.66;
- c) containing a leucine zipper motif;
- and
- d) binding to a kinase involved in the activation of NF-κB.
Dependencies are inferred from the claim text.