Natural Polypeptides For Oral Health Care
AssigneeUniversity of Medicine and Dentistry of New Jersey
InventorsDaniel Fine, Narayanan Ramasubbu
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Abstract
The present invention relates generally to dental diseases, caries and periodontal disease. More specifically, the invention relates to Lactoferrin and Statherin fusion proteins (STAT-LF) along with therapeutic, diagnostic and research uses for these polypeptides. The present invention also provides methods of treating dental diseases, caries and periodontal disease.
Claims30
A composition for inhibiting bacterial growth in the oral cavity comprising a fusion protein comprising:
- i. a lysine form of a Lactoferrin polypeptide or a functionally equivalent peptide molecule thereof;
- and
- ii. a Statherin polypeptide or a functionally equivalent peptide molecule thereof.
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A method for inhibiting bacteria in the oral cavity comprising administering an effective amount of a composition comprising a fusion protein comprising:
- i. a lysine form of a Lactoferrin polypeptide or a functionally equivalent peptide molecule thereof;
- and
- ii. a Statherin polypeptide or a functionally equivalent peptide molecule thereof
- to a patient in need thereof.
A method for the treatment or prevention of an oral health condition comprising administering an effective amount of a composition comprising a fusion protein comprising:
- i. a lysine form of a Lactoferrin polypeptide or a functionally equivalent peptide molecule thereof;
- and
- ii. a Statherin polypeptide or a functionally equivalent peptide molecule thereof
- to a patient in need thereof.
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A fusion protein having SEQ ID NO. 10;
- SEQ ID NO. 11;
- or SEQ ID NO. 13, or a functionally equivalent peptide molecule thereof.
Dependencies are inferred from the claim text.