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US 2010/0144595 A1Published application
Lyophilization of Hemoglobin Solutions
OwnerEnrico Bucciinventor
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Abstract
A lyophilized hemoglobin composition and a method for lyophilizing hemoglobin are described. The method of the invention produces a reconstituted hemoglobin solution which is not altered in functional properties from the hemoglobin solution prior to lyophilization.
Claims22
A lyophilized hemoglobin composition, said composition produced by lyophilizing a hemoglobin aqueous solution comprising:
- a stabilizing agent selected from the group consisting of saccharide, disaccharide, polysaccharide, and soluble polymer;
- and
- a buffering agent.
A method for producing a lyophilized hemoglobin comprising
- dialyzing a hemoglobin solution against a solution comprising a stabilizing agent selected from the group consisting of a saccharide, a disaccharide, a polysaccharide, and a soluble polymer and a buffering agent to produce a dialyzed hemoglobin solution;
- and
- lyophilizing said dialyzed hemoglobin solution.
A method for producing lyophilized hemoglobin comprising
- adding to a hemoglobin solution a stabilizing agent selected from the group consisting of a saccharide, a disaccharide, a polysaccharide, and a soluble polymer to produce a hemoglobin-stabilizing agent solution.
Dependencies are inferred from the claim text.