2-heteroaryl-pyrrolo[3,4-c]pyrrole derivatives and their use as scd inhibitors

A compound of formula I,

• wherein:
• R is hydrogen, (C1-C16)-alkyl, (C1-C5)-alkyloxy, (C1-C5)-alkylthio, (C1-C5)-alkylamino, di-(C2-C8)-alkylamino, (C0-C4)-alkylene-(C6-C10)-aryl, (C0-C4)-alkylene-(C5-C12)-heteroaryl, (C0-C4)-alkylene-(C3-C12)-heterocyclyl, (C0-C4)-alkylene-(C3-C12)-cycloalkyl, or a bicyclic (C8-C14) ring system,
• wherein the aryl, heteroaryl, heterocyclyl, cycloalkyl or bicyclic (C8-C14) ring system may be mono- or polysubstituted by halogen, (C1-C6)-alkyl, (C1-C3)-alkyloxy, hydroxyl, (C1-C6)-alkylmercapto, amino, (C1-C6)-alkylamino, di-(C2-C12)-alkylamino, mono-(C1-C6)-alkylamino-carbonyl, di-(C2-C8)-alkylaminocarbonyl, (C1-C6)-alkoxycarbonyl, (C1-C6)-alkylcarbonyl, cyano, trifluoromethyl, trifluoromethyloxy, (C1-C6)-alkylsulfonyl or aminosulfonyl;
• R1 is hydrogen, (C1-C10-alkyl, (C1-C10)-alkyloxy, amino, mono-(C1-C10)-alkylamino, or di-(C2-C12)-alkylamino,
• Wherein the alkyl may be substituted by halogen, (C1-C6)-alkyl, (C1-C3)-alkyloxy, hydroxyl, (C1-C6)-alkylmercapto, amino, (C1-C6)-alkylamino, di-(C2-C12)-alkylamino, —(C6-C10)-aryl, —(C5-C12)-heteroaryl, —(C3-C12)-heterocyclyl or —(C3-C12)-cycloalkyl,
• Wherein the aryl, heteroaryl, heterocyclyl or cycloalkyl may be mono- or polysubstituted by halogen, (C1-C6)-alkyl, (C1-C3)-alkyloxy, hydroxyl, (C1-C6)-alkylmercapto, amino, (C1-C6)-alkylamino, or di-(C2-C12)-alkylamino;
• R2 is hydrogen, (C1-C16)-alkyl, or (C0-C4)-alkylene-(C6-C10)-aryl;
• R3 is hydrogen, (C1-C6)-alkyl, (C1-C3)-alkyloxy, hydroxyl, (C1-C6)-alkylmercapto, amino, (C1-C6)-alkylamino, di-(C2-C12)-alkylamino, cyano, (C1-C6)-alkylcarbonyl, halogen, trifluoromethyl, trifluoromethyloxy, (C1-C6)-alkylsulfonyl, or aminosulfonyl;
• A is O, S, N(R2), C(R3), C(R3)=C(R3), NH═C(R3), C(R3)=NH, or NH═NH;
• B is C(R3), or N;
• D is C(R3), or N;
• provided that at least one of A, B and D must be nitrogen;
• n is 1 or 2;
• L is a bond, —C(═O)—, —C(═S)—, —C(═O)—N(R2)-, —C(═O)—O—, —S(O)0-2—, —S(O)0-2—N(R2)-, or a mono- or bicyclic ring system in which one or more ring members may be N(R3), O, S or —C(═O)—;
• and
• M is —C(═O)—N(R2)-, —N(R2)-C(═O)—, —S(O)0-2—, —S(O)0-2—N(R2)-, —N(R2)-S(O)0-2—, —C(═O)—O—, or —O—C(═O)—;
• or a physiologically compatible salt thereof.