Frequency modulated drug delivery (FMDD)
AssigneeSynthonics, Inc.
InventorsThomas Piccariello, Scott B. Palmer, John D. Price, Robert Oberlender, Mary C. Spencer, Michaela E. Mulhare
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Abstract
Embodiments of the present disclosure include a coordination complex, comprising a first biologically active moiety, a second biologically active moiety, and a metal, wherein the first biologically active moiety and second biologically active moiety are bound to the metal by covalent coordination bonds, and wherein the first biologically active moiety and second biologically active moiety are different. These complexes may enhance the pharmacodynamic properties of biologically active moieties.
Claims28
A coordination complex, comprising:
- a first biologically active moiety;
- a second biologically active moiety;
- and
- a metal,
- wherein the first biologically active moiety and second biologically active moiety are each bound to the metal by at least one binding site,
- wherein the first biologically active moiety and second biologically active moiety are different;
- and
- wherein the first biologically active moiety and the second biologically active moiety both have a biological effect on a target tissue.
A method for enhancing the biological effect of biologically active moieties, comprising:
- forming a coordination complex comprising a first biologically active moiety, a second biologically active moiety, and a metal,
- wherein the first biologically active moiety and the second biologically active moiety are each bound to the metal by at least one binding site,
- wherein the first biologically active moiety and the second biologically active moiety are different, and
- wherein the first biologically active moiety and the second biologically active moiety both have a biological effect on a target tissue.
A method of treatment, comprising:
- administering a coordination complex comprising at least a first biologically active moiety, a second biologically active moiety, and a metal,
- wherein the first biologically active moiety and the second biologically active moiety both have a biological effect on a target tissue.
Dependencies are inferred from the claim text.