Systems and methods for biodosimetry with biochip using gene expression signatures
AssigneeThe Trustees of Columbia University in the City of New York
InventorsFrederic Zenhausern, Christine Orozco, Mark Richards, Carl Yamashiro, Sally A. Amundson, Ralf Lenigk, Michael L. Bittner, Yoganand Balagurunathan
Life of this patent
Estimating the term…
Abstract
Exposure to ionizing radiation can produce a well-defined dose dependent signature in terms of changes in gene expression. In approaches and devices described herein, such a signature can be used to generate and use a self-contained radiation biodosimeter device, based on, for example, a blood finger stick. Various aspects of the invention are directed to biodosimetry with a fully integrated biochip using gene expression signatures.
Claims34
1-56. (canceled)
A portable biodosimetry device for detecting radiation exposure, comprising:
- a microfluidic biochip comprising:
- a biological sample collection module;
- an oligonucleotide extraction module;
- a hybridization channel module;
- a power module;
- and
- a control module;
- wherein,
- the hybridization channel module comprises an oligonucleotide array;
- the oligonucleotide array of the hybridization channel module comprises a plurality of oligonucleotides, where an oligonucleotide of the array will hybridize under stringent conditions to a gene expression product of a radiation responsive gene;
- and
- the biological sample collection module, the oligonucleotide extraction module, and the hybridization channel module are fluidically coupled.
(canceled)
63-64. (canceled)
(canceled)
(canceled)
(canceled)
73-75. (canceled)
78-83. (canceled)
(canceled)
(canceled)
91-95. (canceled)
101-104. (canceled)
Dependencies are inferred from the claim text.