Placental protein having a regulating action on proteolytic activity and its related gene

Abstract

The present invention is intended to provide a novel pharmaceutical composition containing a protein that does not have a known protein motif structure but has proteolytic activity and regulating action on the activity of other proteases, cell invasiveness and smooth muscle contraction and relaxation, and is capable of treating, preventing and diagnosing various diseases. The invention provides a pharmaceutical composition for the treatment, prevention or diagnosis of a disease selected from the group consisting of perinatal diseases, infertility, cancer, nervous system diseases, inflammatory diseases, immune diseases, cardiovascular diseases, endocrine diseases, viral infections, bacterial infections and prion diseases, which contains a protein shown in Sequence listing 1 or an antibody specific thereto. Furthermore, the invention also provides a recombinant vector for the treatment, prevention or diagnosis of a disease selected from the group consisting of perinatal diseases, infertility, cancer, nervous system diseases, inflammatory diseases, immune diseases, cardiovascular diseases, endocrine diseases, viral infections, bacterial infections and prion diseases, which contains a gene shown in Sequence listing 2 and encoding the protein shown in Sequence listing 1 or a gene shown in Sequence listing 3 or 4, and being a splice variant thereof.

Dependencies are inferred from the claim text.