R-hnl random variants and their use for preparing optically pure, sterically hindered cyanohydrins
AssigneeDsm IP Assets B.V.
InventorsRichard Gaisberger, Anton Glieder, Zhibin Liu, Beate Pscheidt
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Abstract
The invention relates to R-hydroxynitrile lyases with improved substrate acceptance, increased activity and increased selectivity, obtainable by introducing random mutations with the aid of random mutagenesis and/or saturation mutagenesis techniques, identifying by means of screening or selection and, where appropriate, subsequently combining advantageous mutations, and to the use thereof.
Claims14
An R-hydroxynitrile lyase with improved substrate acceptance, increased activity and increased selectivity, obtainable by introducing random mutations with the aid of random mutagenesis and/or saturation mutagenesis techniques, identifying by means of screening or selection and, where appropriate, subsequently combining advantageous mutations.
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Dependencies are inferred from the claim text.