Detection of Soluble Adiponectin Receptor Peptides and Use in Diagnostics and Therapeutics

A method of detecting the level of expression of an adiponectin receptor in a subject comprising the step of determining the level of at least one C-terminal fragment of the adiponectin receptor in a biological fluid sample and correlating the level of the at least one C-terminal fragment with the level of expression of the adiponectin receptor.

A method of detecting the level of expression of adiponectin in a subject comprising the step of determining the level of at least one C-terminal fragment of the adiponectin receptor in a biological fluid sample and correlating the level of the at least one C-terminal fragment with the level of expression of adiponectin.

A method for determining progression of a condition, onset of a condition, or efficacy of treatment of a condition characterized by an adipocyte imbalance in a subject comprising determining the level of at least one soluble C-terminal fragment of the adiponectin receptor present in a bodily fluid sample obtained from the subject and correlating the level with progression of the condition, onset of the condition, or efficacy of treatment of the condition.

A method for determining whether a subject having arteriosclerosis is likely to develop cardiovascular disease comprising determining the level of at least one soluble C-terminal fragment of the adiponectin receptor present in a biological fluid sample obtained from the subject and correlating the level with the likelihood of development of cardiovascular disease.