Reagents and methods for use in cancer diagnosis, classification and therapy
AssigneeClarient Diagnostic Services, Inc.
InventorsBrian Z. Ring, Douglas T. Ross, Robert S. Seitz
Life of this patent
Estimating the term…
Abstract
Methods and reagents for classifying HER2+ breast tumors and for identifying new HER2+ breast tumor classes and subclasses. Methods for correlating tumor class or subclass with therapeutic regimen or outcome, for identifying appropriate (new or known) therapies for particular classes or subclasses, and for predicting outcomes based on class or subclass. New therapeutic agents and methods for the treatment of HER2+ breast cancer.
Claims23
A method comprising steps of:
- obtaining a tumor sample from a patient having an HER2+ breast tumor;
- contacting the tumor sample with a first antibody directed to the HTF9C marker;
- and
- assessing the patient's likely prognosis based upon binding of the first antibody to the tumor sample.
A method comprising steps of:
- obtaining a tumor sample from a patient having an HER2+ breast tumor;
- contacting the tumor sample with a first antibody directed to the HTF9C marker;
- and
- classifying the HER2+ breast tumor based upon binding of the first antibody to the tumor sample.
A method comprising steps of:
- obtaining a tumor sample from a patient having an HER2+ breast tumor;
- contacting the sample with a first antibody directed to the HTF9C marker;
- and
- assessing the patient's likely response to therapy based upon binding of the first antibody to the tumor sample.
A kit comprising:
- a first antibody directed to the HTF9C marker;
- and
- a second antibody directed to the HER2 marker.
A therapeutic agent for the treatment of HER2+ breast cancer comprising an antibody directed to the HTF9C marker.
A method comprising steps of:
- contacting a test compound with a cell expressing the HTF9C marker;
- and
- determining whether the test compound modulates the expression, localization, modification, or activity of the HTF9C marker.
Dependencies are inferred from the claim text.