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US 2010/0143945 A1Published application
Dna-damage-induced proteolysis
AssigneeCalifornia Institute of Technology
InventorsAli Khoshnan, Paul H. Patterson
Life of this patent
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Abstract
The present application provides methods for identifying compounds for inhibiting DNA damage-induced Htt proteolysis, and methods and compositions for protecting cells from DNA damage-induced cleavage of Htt.
Claims35
A method of identifying a compound for protecting a cell from DNA damage-induced Htt proteolysis, comprising:
- providing one or more compounds to be tested;
- identifying which compound is an IKKβ inhibitor;
- testing the compound identified as the IKKβ inhibitor for its ability to reduce cleavage of Htt in a cell.
A method of identifying a compound for protecting a cell from DNA damage-induced Htt proteolysis, comprising:
- providing one or more compound to be tested;
- identifying which compound is selected from the group consisting of IKKα activator, Bcl-xL inducer, and some combination thereof;
- testing the compound identified as an IKKα activator, Bcl-xL inducer, or some combination thereof for its ability to reduce the cleavage of Htt in a cell.
A method for protecting at least one cell from DNA damage, comprising
- inhibiting DNA damage-induced Htt proteolysis in at least one cell by contacting said at least one cell with at least one compound selected from the group consisting of an IKKβ inhibitor, an IKKα, activator, and a Bcl-xL inducer.
A kit for screening IKKα activator, comprising:
- a DNA damaging agent;
- and
- a means for monitoring DNA damage-induced Htt proteolysis.
Dependencies are inferred from the claim text.