c-KIT Phosphorylation in Cancer
AssigneeApocell, Inc.
InventorDarren W. Davis
Life of this patent
Estimating the term…
Abstract
An antibody is disclosed for the detection of phosphorylated c-KIT. A method of diagnosing and monitoring cancers responsive to treatment using an anti-phospho-c-KIT antibody are also disclosed. A diagnostic kit is also provided for the detection and monitoring of cancers responsive to tyrosine phosphorylation inhibitor treatment.
Claims23
An antibody that binds specifically to phosphorylated c-KIT, wherein said antibody binds a single epitope and does not bind to non-phosphorylated c-KIT.
A method of predicting cancer response to treatment comprising:
- a) isolating a sample from a patient;
- b) adding an antibody specific for phosphorylated c-KIT;
- c) detecting binding of said antibody to phosphorylated c-KIT in said sample;
- and
- d) identifying said patient as having a cancer responsive to treatment with an inhibitor of c-KIT phosphorylation.
A method of monitoring patient response to cancer treatment comprising:
- a) isolating a sample from a patient with a cancer;
- b) adding an antibody specific for phosphorylated c-KIT;
- c) detecting binding of said antibody to phosphorylated c-KIT in said sample;
- d) repeating a), b), and c) after one or more treatments;
- and
- e) determining response of said cancer to treatment
- wherein a decrease in antibody binding indicates a remission of said cancer.
A kit for the detection of a cancer responsive to treatment comprising:
- a) an antibody specific for phosphorylated c-KIT;
- b) a detection antibody that binds said antibody specific for phosphorylated c-KIT;
- c) a detection reagent that specifically reacts with the detection antibody;
- and
- d) an optional control sample containing samples of known c-KIT phosphorylation.
Dependencies are inferred from the claim text.