Surfactant Protein D is a Biomarker for Steroid Responsiveness in Asthma and Chronic Obstructive Pulmonary Disease
AssigneeThe Trustees of the University of Pennsylvania
InventorsReynold A. Panettieri, Jr., Michael F. Beers, Angela F. Haczku, Michael W. Sims
Life of this patent
Estimating the term…
Abstract
The present invention relates to the identification of a biomarker, the detection of which is prognostic for individuals who are responsive to inhalation of corticosteroids as a therapy for asthma and COPD.
Claims52
A method of identifying an individual having lung disease that is responsive to treatment for said lung disease, said method comprising measuring the level of a biomarker in a body sample obtained from said individual, wherein when the level of said biomarker in said sample is greater than the level of the same biomarker in an otherwise identical sample obtained from the same individual prior to commencement of treatment, this is an indication that said individual is responsive to said treatment.
A method of assessing the efficacy of a treatment for lung disease in an individual, said method comprising obtaining a first sample from said individual having said lung disease and measuring the level of SP-D in said first sample, obtaining a second sample from the same individual at a time subsequent to obtaining said first sample, wherein said time is subsequent to the onset of treatment, and measuring the level of SP-D in said second sample, wherein when the level of SP-D is higher in said second sample than the level of SP-D in said first sample, said treatment is efficacious.
A composition comprising a plurality of oligonucleotides attached to a substrate surface, wherein each of said oligonucleotides is a nucleic acid encoding a biomarker or a fragment thereof, or is complementary to said biomarker or said fragment thereof, wherein said biomarker is surfactant protein D.
A composition comprising a plurality of peptides attached to a substrate surface, wherein each of said peptides is a biomarker or a fragment thereof, wherein said biomarker is surfactant protein D.
A composition comprising a plurality of antibodies attached to a substrate surface wherein said antibody specifically binds a biomarker or a fragment thereof, wherein said biomarker is surfactant protein D.
A kit comprising a composition for measuring the level of a biomarker in a body sample, said kit comprising at least one antibody that specifically binds said biomarker or a fragment thereof, said kit comprising instructional material for the use thereof.
A kit comprising a composition for measuring the level of a biomarker in a body sample, said kit comprising at least one nucleic acid, wherein said nucleic acid encodes said biomarker or a fragment thereof, or is complementary to said biomarker or a fragment thereof, said kit further comprising an instructional material for the use thereof.
Dependencies are inferred from the claim text.