Method for the genomic typing of erythrocyte systems, oligonucleotide probes and relative diagnostic kits

A set of oligonucleotide probes amino-modified at the 5′-end, characterized in that they have a sequence length ranging from 18 to 20 nucleotides containing at or near the center of the probe sequence the specific SNP for each of the target alleles belonging to the genomic locus X, selected from K/k, Kpa/Kpb, Jsa/Jsb, Lua/Lub, S/s, Coa/Cob, Fya/Fyb, Jka/Jkb capable of specifically hybridizing to each of said alleles;

• said probes being characterized in that they are coupled to a microsphere labeled with at least one fluorescent substance and that they comprise or consist of at least one set of oligonucleotide sequences indicated in the following table:
• Probe
• set
• Probe
• Probe set
• number
• k
• TTAACCgAACgCTgAgAC (SEQ ID NO:
• 17)
• 1
• K
• TTAACCgAATgCTgAgAC (SEQ ID NO:
• 18)
• NC
• CTATCCCAAAgCTAAggC (SEQ ID NO:
• 19)
• Kpb
• ATCACTTCACggCTgTTCCA (SEQ ID NO:
• 20)
• 2
• Kpa
• TCACTTCATggCTgTTCCAg (SEQ ID NO:
• 21)
• NC
• AACTCTACAgggCTCTTCgA (SEQ ID NO:
• 22)
• Jsb
• ggCTgCCTCgCCTgTgACAA (SEQ ID NO:
• 23)
• 3
• Jsa
• ggCTgCCCCgCCTgTgACAA (SEQ ID NO:
• 24)
• NC
• gCCAgCCACgCgTgTCACTA (SEQ ID NO:
• 25)
• Lua
• TCgCCCCCgCCTAgCCTC (SEQ ID NO:
• 26)
• 4
• Lub
• TCgCCCCCACCTAgCCTC (SEQ ID NO:
• 27)
• NC
• TAgCCTCCTCCAAgACTA (SEQ ID NO:
• 28)
• s
• TAggAgAAACgggACAACTT (SEQ ID NO:
• 29)
• 5
• S
• AggAgAAATgggACAACTTg (SEQ ID NO:
• 30)
• NC
• TCggATAAAAgAgACCACTg (SEQ ID NO:
• 31)
• Coa
• AACCAgACggCggTCCAggA (SEQ ID NO:
• 32)
• 6
• Cob
• CAACCAgACggTggTCCAgg (SEQ ID NO:
• 33)
• NC
• AgCCACACTggggACCTggA (SEQ ID NO:
• 34)
• Fya
• GAgACTATggTgCCAACCTg (SEQ ID NO:
• 35)
• 7
• Fyb
• TggAgACTATgATgCCAACC (SEQ ID NO:
• 36)
• NC
• gAggCTATCCTgACAAgCTT (SEQ ID NO:
• 37)
• Jka
• AGTAGATGTCCTCAAATG (SEQ ID NO:
• 38)