Methods and Compositions for Inhibiting GSK-3 In Glial Cell Related Disorders
AssigneeThe Ohio State University Research Foundation
InventorsSean E. Lawler, Michal Oskar Nowicki, E. Antonio Chiocca
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Abstract
A method of treating a glial cell related disorder in a mammalian subject includes administering a drug which enhances or prolongs GSK-3 α or β inactivation.
Claims20
A method of treating a glial cell related disorder in a mammalian subject comprising administering a drug to the subject, wherein the drug enhances or prolongs GSK-3 α or β inactivation.
A method for screening or identifying a compound useful in treating glial cell related disorders, comprising identifying inhibitory and stimulatory compounds capable of enhancing or prolonging GSK-3 α or β inactivation.
A medicament for treating a glial cell related disorder in a mammalian subject comprising administering a drug to the subject, wherein the medicament comprises a drug which drug enhances or prolongs GSK-3 α or β inactivation.
A biomarker for glioma cell invasion or migration comprising glycogen synthase kinase-3 (GSK-3).
A method for evaluating invasion or migration of glial cells comprising using glycogen synthase kinase-3 (GSK-3) as a biomarker therefor.
Dependencies are inferred from the claim text.